RT Journal
A1 McGuire, R E
A1 Jordan, S A
A1 Braden, V V
A1 Bouffard, G G
A1 Humphries, P
A1 Green, E D
A1 Daiger, S P
T1 Mapping the RP10 locus for autosomal dominant retinitis pigmentosa on 7q: refined genetic positioning and localization within a well-defined YAC contig.
JF Genome Research 
JO Genome Research 
YR 1996 
FD April 01 
VO 6 
IS 4 
SP 255 
OP 266 
DO 10.1101/gr.6.4.255 
UL http://genome.cshlp.org/content/6/4/255.abstract 
AB Retinitis pigmentosa is a genetically heterogeneous disease that has autosomal dominant, autosomal recessive and X-linked forms. Autosomal dominant retinitis pigmentosa (adRP) has thus far been associated with eight distinct loci, including the rhodopsin and peripherin/RDS genes as well as unidentified genes on chromosomes 7p, 7q, 8q, 17p, 17q, and 19q. The RP10 locus for adRP on chromosome 7q was first mapped in a Spanish family; later, an unrelated American family was identified that also showed linkage to 7q. By combining the linkage results from both families, we are able to assign the disease gene to a 5-cM interval on 7q. Based on extensive physical mapping of this region, the genetic interval is now fully contained within a approximately 5-Mb segment on a well-defined YAC contig. These studies significantly reduce the size of the RP10 critical region, exclude a number of possible candidate genes, and provide the necessary cloned DNA for the positional cloning of the RP10 gene.