RT Journal
A1 Edwards, Y H
A1 Putt, W
A1 Lekoape, K M
A1 Stott, D
A1 Fox, M
A1 Hopkinson, D A
A1 Sowden, J
T1 The human homolog T of the mouse T(Brachyury) gene; gene structure, cDNA sequence, and assignment to chromosome 6q27.
JF Genome Research 
JO Genome Research 
YR 1996 
FD March 01 
VO 6 
IS 3 
SP 226 
OP 233 
DO 10.1101/gr.6.3.226 
UL http://genome.cshlp.org/content/6/3/226.abstract 
AB We have cloned the human gene encoding the transcription factor T. T protein is vital for the formation of posterior mesoderm and axial development in all vertebrates. Brachyury mutant mice, which lack T protein, die in utero with abnormal notochord, posterior somites, and allantois. We have identified human T genomic clones and derived the mRNA sequence and gene structure. There is 91% amino acid identity between human and mouse T proteins overall and complete identity across 77 amino acids of the T-box motif within the DNA-binding domain. Human T expression is very similar to that found for T in other vertebrate species and is confined to cells derived from the notochord. The human T gene maps to chromosome 6q27 and is only the second human member of the T-box gene family to be described.