TY - JOUR A1 - McKinnon, P J A1 - Kapsetaki, M A1 - Margolskee, R F T1 - The exon structure of the mouse Sc1 gene is very similar to the mouse Sparc gene. Y1 - 1996/11/01 JF - Genome Research JO - Genome Research SP - 1077 EP - 1083 DO - 10.1101/gr.6.11.1077 VL - 6 IS - 11 UR - http://genome.cshlp.org/content/6/11/1077.abstract N2 - Sc1 and Sparc are two extracellular proteins sharing similarity in their carboxyl terminus, with 63% identity over a 232-amino-acid region. We have cloned and mapped the genomic locus of mouse Sc1. The mouse Sc1 gene contains 11 exons spanning approximately 35 kb of DNA. The genomic structure (exon/intron boundaries) of Sc1 exons 6 to exon 11 is identical to those of the similar portion of the Sparc gene. This suggests that Sc1 and Sparc originated from a common ancestral gene. Using fluorescence in situ hybridization analysis, Sc1 was localized to band 5E4 of mouse chromosome 5. ER -