TY - JOUR A1 - Feng, J A1 - Li, Y A1 - Hashad, M A1 - Schurr, E A1 - Gros, P A1 - Adams, L G A1 - Templeton, J W T1 - Bovine natural resistance associated macrophage protein 1 (Nramp1) gene. Y1 - 1996/10/01 JF - Genome Research JO - Genome Research SP - 956 EP - 964 DO - 10.1101/gr.6.10.956 VL - 6 IS - 10 UR - http://genome.cshlp.org/content/6/10/956.abstract N2 - The Bcg/Ity/Lsh locus is a major gene controlling early phases of infection with intracellular parasites in mice. Natural resistance associated macrophage protein 1 (Nramp1) has been shown to be the Bcg gene in mice. Analysis of a bovine cDNA homolog of murine Nramp1, designated as bovine NRAMP1, predicted a 548-amino-acid protein with hydrophobic domains, an amino-terminal SH3-binding domain, and a conserved consensus transport motif. Northern blotting indicated that bovine NRAMP1 was expressed primarily in macrophages and tissues of the recticuloendothelial system. Bovine NRAMP1 was mapped to BTA 2 within syntenic loci conserved on HSA 2q and MMU 1. ER -