RT Journal
A1 Kawasaki, K
A1 Minoshima, S
A1 Schooler, K
A1 Kudoh, J
A1 Asakawa, S
A1 de Jong, P J
A1 Shimizu, N
T1 The organization of the human immunoglobulin lambda gene locus.
JF Genome Research 
JO Genome Research 
YR 1995 
FD September 01 
VO 5 
IS 2 
SP 125 
OP 135 
DO 10.1101/gr.5.2.125 
UL http://genome.cshlp.org/content/5/2/125.abstract 
AB To elucidate the complex structure of the human immunoglobulin lambda gene locus, a 1020-kb contig was constructed using 184 cosmid clones and one bacterial artificial chromosome (BAC) clone. A high-resolution physical map of this contig revealed that the entire lambda gene locus is 911 kb in length. It contains seven constant region (C lambda) gene segments and 69 unique EcoRI-HindIII segments that hybridize to variable region gene (V lambda) probes. The VpreB gene, BCRL4, and gamma-glutamyl transpeptidase gene (GGT)-like sequences are also located within the lambda gene locus. Hybridization analysis suggested that the lambda gene locus has undergone extensive amplification events in evolution.