TY  - JOUR
A1  - Pekkarinen, P
A1  - Terwilliger, J
A1  - Bredbacka, P E
A1  - Lönnqvist, J
A1  - Peltonen, L
T1  - Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.
Y1  - 1995/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 105 
EP  - 115 
DO  - 10.1101/gr.5.2.105 
VL  - 5 
IS  - 2 
UR  - http://genome.cshlp.org/content/5/2/105.abstract 
N2  - An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have remained controversial. We report here a linkage between DNA markers near the coagulation factor IX gene and bipolar disorder in an extended pedigree rising from the genetically isolated population of Finland. A distinct chromosomal haplotype covering a 20-cM region on Xq24-q27.1 could be demonstrated to segregate with bipolar disorder. These findings should encourage research groups to study extended family materials with Xq24-q27.1 markers to finally resolve the question of the X-chromosomal linkage of bipolar disorder. 
ER  -