TY  - JOUR
A1  - Thomas, William R.
A1  - Baldoni, Cecilia
A1  - Zeng, Yuanyuan
A1  - Carlson, David
A1  - Holm-Jacobsen, Julie
A1  - Muturi, Marion
A1  - von Elverfeldt, Dominik
A1  - Bennike, Tue B.
A1  - Dechmann, Dina K.N.
A1  - Nieland, John
A1  - Corthals, Angelique P.
A1  - Dávalos, Liliana M.
T1  - Dynamic metabolic and molecular changes during seasonal shrinking in Sorex araneus
Y1  - 2026/01/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 61 
EP  - 70 
DO  - 10.1101/gr.280639.125 
VL  - 36 
IS  - 1 
UR  - http://genome.cshlp.org/content/36/1/61.abstract 
N2  - To meet the challenge of wintering in place, many high-latitude small mammals reduce energy demands through hibernation. In contrast, short-lived Eurasian common shrews, Sorex araneus, remain active and shrink, including energy-intensive organs in winter, regrowing in spring in an evolved strategy called Dehnel's phenomenon. How this size change is linked to metabolic and regulatory changes to sustain their high metabolism is unknown. Here, we analyze metabolic, proteomic, and gene expression profiles spanning the entirety of Dehnel's seasonal cycle in wild shrews. We show regulatory changes to oxidative phosphorylation and increased fatty acid metabolism during autumn-to-winter shrinkage, as previously found in hibernating species. But in shrews, we also find upregulated winter expression of genes involved in gluconeogenesis: the biosynthesis of glucose from noncarbohydrate substrates. Coexpression models reveal changes in size and metabolic gene expression coordinated via FOXO signaling, whose overexpression reduces size and extends life span in many model organisms. We propose that although shifts in gluconeogenesis meet the challenge posed by high metabolic rate and active winter lifestyle, FOXO signaling is central to Dehnel's phenomenon, with spring downregulation limiting life span in these shrews. 
ER  -