TY  - JOUR
A1  - Montano, Carolina
A1  - Timp, Winston
T1  - Evolution of genome-wide methylation profiling technologies
Y1  - 2025/04/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 572 
EP  - 582 
DO  - 10.1101/gr.278407.123 
VL  - 35 
IS  - 4 
UR  - http://genome.cshlp.org/content/35/4/572.abstract 
N2  - In this mini-review, we explore the advancements in genome-wide DNA methylation profiling, tracing the evolution from traditional methods such as methylation arrays and whole-genome bisulfite sequencing to the cutting-edge single-molecule profiling enabled by long-read sequencing (LRS) technologies. We highlight how LRS is transforming clinical and translational research, particularly by its ability to simultaneously measure genetic and epigenetic information, providing a more comprehensive understanding of complex disease mechanisms. We discuss current challenges and future directions in the field, emphasizing the need for innovative computational tools and robust, reproducible approaches to fully harness the capabilities of LRS in molecular diagnostics. 
ER  -