TY  - JOUR
A1  - Liu, Yulong
A1  - Zhai, Gang
A1  - Su, Jingzhi
A1  - Gong, Yulong
A1  - Yang, Bingyuan
A1  - Lu, Qisheng
A1  - Xi, Longwei
A1  - Zheng, Yutong
A1  - Cao, Jingyue
A1  - Liu, Haokun
A1  - Jin, Junyan
A1  - Zhang, Zhimin
A1  - Yang, Yunxia
A1  - Zhu, Xiaoming
A1  - Wang, Zhongwei
A1  - Gong, Gaorui
A1  - Mei, Jie
A1  - Yin, Zhan
A1  - Gozlan, Rodolphe E.
A1  - Xie, Shouqi
A1  - Han, Dong
T1  - The Chinese longsnout catfish genome provides novel insights into the feeding preference and corresponding metabolic strategy of carnivores
Y1  - 2024/07/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 981 
EP  - 996 
DO  - 10.1101/gr.278476.123 
VL  - 34 
IS  - 7 
UR  - http://genome.cshlp.org/content/34/7/981.abstract 
N2  - Fish show variation in feeding habits to adapt to complex environments. However, the genetic basis of feeding preference and the corresponding metabolic strategies that differentiate feeding habits remain elusive. Here, by comparing the whole genome of a typical carnivorous fish (Leiocassis longirostris Günther) with that of herbivorous fish, we identify 250 genes through both positive selection and rapid evolution, including taste receptor taste receptor type 1 member 3 (tas1r3) and trypsin. We demonstrate that tas1r3 is required for carnivore preference in tas1r3-deficient zebrafish and in a diet-shifted grass carp model. We confirm that trypsin correlates with the metabolic strategies of fish with distinct feeding habits. Furthermore, marked alterations in trypsin activity and metabolic profiles are accompanied by a transition of feeding preference in tas1r3-deficient zebrafish and diet-shifted grass carp. Our results reveal a conserved adaptation between feeding preference and corresponding metabolic strategies in fish, and provide novel insights into the adaptation of feeding habits over the evolution course. 
ER  -