TY  - JOUR
A1  - Ji, Shuangxi
A1  - Zhu, Tong
A1  - Sethia, Ankit
A1  - Wang, Wenyi
T1  - Accelerated somatic mutation calling for whole-genome and whole-exome sequencing data from heterogenous tumor samples
Y1  - 2024/04/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 633 
EP  - 641 
DO  - 10.1101/gr.278456.123 
VL  - 34 
IS  - 4 
UR  - http://genome.cshlp.org/content/34/4/633.abstract 
N2  - Accurate detection of somatic mutations in DNA sequencing data is a fundamental prerequisite for cancer research. Previous analytical challenges were overcome by consensus mutation calling from four to five popular callers. This, however, increases the already nontrivial computing time from individual callers. Here, we launch MuSE 2, powered by multistep parallelization and efficient memory allocation, to resolve the computing time bottleneck. MuSE 2 speeds up 50 times more than MuSE 1 and eight to 80 times more than other popular callers. Our benchmark study suggests combining MuSE 2 and the recently accelerated Strelka2 achieves high efficiency and accuracy in analyzing large cancer genomic data sets. 
ER  -