RT Journal
A1 de Tribolet-Hardy, Jonas
A1 Thorball, Christian W.
A1 Forey, Romain
A1 Planet, Evarist
A1 Duc, Julien
A1 Coudray, Alexandre
A1 Khubieh, Bara
A1 Offner, Sandra
A1 Pulver, Cyril
A1 Fellay, Jacques
A1 Imbeault, Michael
A1 Turelli, Priscilla
A1 Trono, Didier
T1 Genetic features and genomic targets of human KRAB-zinc finger proteins
JF Genome Research 
JO Genome Research 
YR 2023 
FD August 01 
VO 33 
IS 8 
SP 1409 
OP 1423 
DO 10.1101/gr.277722.123 
UL http://genome.cshlp.org/content/33/8/1409.abstract 
AB Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) are one of the largest groups of transcription factors encoded by tetrapods, with 378 members in human alone. KZFP genes are often grouped in clusters reflecting amplification by gene and segment duplication since the gene family first emerged more than 400 million years ago. Previous work has revealed that many KZFPs recognize transposable element (TE)-embedded sequences as genomic targets, and that KZFPs facilitate the co-option of the regulatory potential of TEs for the benefit of the host. Here, we present a comprehensive survey of the genetic features and genomic targets of human KZFPs, notably completing past analyses by adding data on close to a hundred family members. General principles emerge from our study of the TE-KZFP regulatory system, which point to multipronged evolutionary mechanisms underlaid by highly complex and combinatorial modes of action with strong influences on human speciation.