@article{Metzger01112023,
author = {Metzger, David C.H. and Porter, Imogen and Mobley, Brendan and Sandkam, Benjamin A. and Fong, Lydia J.M. and Anderson, Andrew P. and Mank, Judith E.}, 
title = {Transposon wave remodeled the epigenomic landscape in the rapid evolution of X-Chromosome dosage compensation},
volume = {33}, 
number = {11}, 
pages = {1917-1931}, 
year = {2023}, 
doi = {10.1101/gr.278127.123}, 
abstract ={Sex chromosome dosage compensation is a model to understand the coordinated evolution of transcription; however, the advanced age of the sex chromosomes in model systems makes it difficult to study how the complex regulatory mechanisms underlying chromosome-wide dosage compensation can evolve. The sex chromosomes of Poecilia picta have undergone recent and rapid divergence, resulting in widespread gene loss on the male Y, coupled with complete X Chromosome dosage compensation, the first case reported in a fish. The recent de novo origin of dosage compensation presents a unique opportunity to understand the genetic and evolutionary basis of coordinated chromosomal gene regulation. By combining a new chromosome-level assembly of P. picta with whole-genome bisulfite sequencing and RNA-seq data, we determine that the YY1 transcription factor (YY1) DNA binding motif is associated with male-specific hypomethylated regions on the X, but not the autosomes. These YY1 motifs are the result of a recent and rapid repetitive element expansion on the P. picta X Chromosome, which is absent in closely related species that lack dosage compensation. Taken together, our results present compelling support that a disruptive wave of repetitive element insertions carrying YY1 motifs resulted in the remodeling of the X Chromosome epigenomic landscape and the rapid de novo origin of a dosage compensation system.}, 
URL = {http://genome.cshlp.org/content/33/11/1917.abstract}, 
eprint = {http://genome.cshlp.org/content/33/11/1917.full.pdf+html}, 
journal = {Genome Research} 
}