@article{Huang01082022,
author = {Huang, Xin and Tang, Xiaohan and Bai, Xuemei and Li, Honglei and Tao, Huan and Wang, Junting and Li, Yaru and Sun, Yu and Zheng, Yang and Xu, Xiang and Wang, Longteng and Ding, Yang and Lu, Meisong and Zhou, Pingkun and Bo, Xiaochen and Li, Hao and Chen, Hebing}, 
title = {dbEmbryo multi-omics database for analyses of synergistic regulation in early mammalian embryo development},
volume = {32}, 
number = {8}, 
pages = {1612-1625}, 
year = {2022}, 
doi = {10.1101/gr.276744.122}, 
abstract ={During early mammalian embryo development, different epigenetic marks undergo reprogramming and play crucial roles in the mediation of gene expression. Currently, several databases provide multi-omics information on early embryos. However, how interconnected epigenetic markers function together to coordinate the expression of the genetic code in a spatiotemporal manner remains difficult to analyze, markedly limiting scientific and clinical research. Here, we present dbEmbryo, an integrated and interactive multi-omics database for human and mouse early embryos. dbEmbryo integrates data on gene expression, DNA methylation, histone modifications, chromatin accessibility, and higher-order chromatin structure profiles for human and mouse early embryos. It incorporates customized analysis tools, such as “multi-omics visualization,” “Gene&Peak annotation,” “ZGA gene cluster,” “cis-regulation,” “synergistic regulation,” “promoter signal enrichment,” and “3D genome.” Users can retrieve gene expression and epigenetic profile patterns to analyze synergistic changes across different early embryo developmental stages. We showed the uniqueness of dbEmbryo among extant databases containing data on early embryo development and provided an overview. Using dbEmbryo, we obtained a phase-separated model of transcriptional control during early embryo development. dbEmbryo offers web-based analytical tools and a comprehensive resource for biologists and clinicians to decipher molecular regulatory mechanisms of human and mouse early embryo development.}, 
URL = {http://genome.cshlp.org/content/32/8/1612.abstract}, 
eprint = {http://genome.cshlp.org/content/32/8/1612.full.pdf+html}, 
journal = {Genome Research} 
}