TY  - JOUR
A1  - Wangkumhang, Pongsakorn
A1  - Greenfield, Matthew
A1  - Hellenthal, Garrett
T1  - An efficient method to identify, date, and describe admixture events using haplotype information
Y1  - 2022/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1553 
EP  - 1564 
DO  - 10.1101/gr.275994.121 
VL  - 32 
IS  - 8 
UR  - http://genome.cshlp.org/content/32/8/1553.abstract 
N2  - We present fastGLOBETROTTER, an efficient new haplotype-based technique to identify, date, and describe admixture events using genome-wide autosomal data. With simulations, we show how fastGLOBETROTTER reduces computation time by an order of magnitude relative to the related technique GLOBETROTTER without suffering loss of accuracy. We apply fastGLOBETROTTER to a cohort of more than 6000 Europeans from 10 countries, revealing previously unreported admixture signals. In particular, we infer multiple periods of admixture related to East Asian or Siberian-like sources, starting >2000 yr ago, in people living in countries north of the Baltic Sea. In contrast, we infer admixture related to West Asian, North African, and/or Southern European sources in populations south of the Baltic Sea, including admixture dated to ∼300–700 CE, overlapping the fall of the Roman Empire, in people from Belgium, France, and parts of Germany. Our new approach scales to analyzing hundreds to thousands of individuals from a putatively admixed population and, hence, is applicable to emerging large-scale cohorts of genetically homogeneous populations. 
ER  -