TY  - JOUR
A1  - Luo, Zhengyu
A1  - Zhang, Ran
A1  - Hu, Tengfei
A1  - Zhu, Yuting
A1  - Wu, Yueming
A1  - Li, Wenfei
A1  - Zhang, Zhi
A1  - Yao, Xuebiao
A1  - Liang, Haiyi
A1  - Song, Xiaoyuan
T1  - NicE-C efficiently reveals open chromatin–associated chromosome interactions at high resolution
Y1  - 2022/03/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 534 
EP  - 544 
DO  - 10.1101/gr.275986.121 
VL  - 32 
IS  - 3 
UR  - http://genome.cshlp.org/content/32/3/534.abstract 
N2  - Enhancer–promoter communication is known to regulate spatiotemporal dynamics of gene expression. Several methods are available to capture enhancer–promoter interactions, but they either require large amounts of starting materials and are costly, or provide a relative low resolution in chromatin contact maps. Here, we present nicking enzyme-assisted open chromatin interaction capture (NicE-C), a method that leverages nicking enzyme–mediated open chromatin profiling and chromosome conformation capture to enable robust and cost-effective detection of open chromatin interactions at high resolution, especially enhancer–promoter interactions. Using TNF stimulation and mouse kidney aging as models, we applied NicE-C to reveal characteristics of dynamic enhancer–promoter interactions. 
ER  -