TY  - JOUR
A1  - Mathieson, Iain
A1  - Terhorst, Jonathan
T1  - Direct detection of natural selection in Bronze Age Britain
Y1  - 2022/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 2057 
EP  - 2067 
DO  - 10.1101/gr.276862.122 
VL  - 32 
IS  - 11-12 
UR  - http://genome.cshlp.org/content/32/11-12/2057.abstract 
N2  - We developed a novel method for efficiently estimating time-varying selection coefficients from genome-wide ancient DNA data. In simulations, our method accurately recovers selective trajectories and is robust to misspecification of population size. We applied it to a large data set of ancient and present-day human genomes from Britain and identified seven loci with genome-wide significant evidence of selection in the past 4500 yr. Almost all of them can be related to increased vitamin D or calcium levels, suggesting strong selective pressure on these or related phenotypes. However, the strength of selection on individual loci varied substantially over time, suggesting that cultural or environmental factors moderated the genetic response. Of 28 complex anthropometric and metabolic traits, skin pigmentation was the only one with significant evidence of polygenic selection, further underscoring the importance of phenotypes related to vitamin D. Our approach illustrates the power of ancient DNA to characterize selection in human populations and illuminates the recent evolutionary history of Britain. 
ER  -