TY  - JOUR
A1  - Ham, Seokjin
A1  - Kim, Sieun S.
A1  - Park, Sangsoon
A1  - Kim, Eun Ji E.
A1  - Kwon, Sujeong
A1  - Park, Hae-Eun H.
A1  - Jung, Yoonji
A1  - Lee, Seung-Jae V.
T1  - Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans
Y1  - 2022/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 2003 
EP  - 2014 
DO  - 10.1101/gr.276515.121 
VL  - 32 
IS  - 11-12 
UR  - http://genome.cshlp.org/content/32/11-12/2003.abstract 
N2  - Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging using Caenorhabditis elegans as a model. Many structural and functional transcript elements, such as noncoding RNAs and intron-derived transcripts, were up-regulated with chronological aging. In contrast, mRNAs with many biological functions, including RNA processing, were down-regulated with physiological aging. We also identified an age-dependent increase in the usage of distal 3′ splice sites in mRNA transcripts as a biomarker of physiological aging. Our study provides crucial information for dissecting chronological and physiological aging at the transcriptomic level. 
ER  -