@article{Ham01112022,
author = {Ham, Seokjin and Kim, Sieun S. and Park, Sangsoon and Kim, Eun Ji E. and Kwon, Sujeong and Park, Hae-Eun H. and Jung, Yoonji and Lee, Seung-Jae V.}, 
title = {Systematic transcriptome analysis associated with physiological and chronological aging in Caenorhabditis elegans},
volume = {32}, 
number = {11-12}, 
pages = {2003-2014}, 
year = {2022}, 
doi = {10.1101/gr.276515.121}, 
abstract ={Aging is associated with changes in a variety of biological processes at the transcriptomic level, including gene expression. Two types of aging occur during a lifetime: chronological and physiological aging. However, dissecting the difference between chronological and physiological ages at the transcriptomic level has been a challenge because of its complexity. We analyzed the transcriptomic features associated with physiological and chronological aging using Caenorhabditis elegans as a model. Many structural and functional transcript elements, such as noncoding RNAs and intron-derived transcripts, were up-regulated with chronological aging. In contrast, mRNAs with many biological functions, including RNA processing, were down-regulated with physiological aging. We also identified an age-dependent increase in the usage of distal 3′ splice sites in mRNA transcripts as a biomarker of physiological aging. Our study provides crucial information for dissecting chronological and physiological aging at the transcriptomic level.}, 
URL = {http://genome.cshlp.org/content/32/11-12/2003.abstract}, 
eprint = {http://genome.cshlp.org/content/32/11-12/2003.full.pdf+html}, 
journal = {Genome Research} 
}