TY  - JOUR
A1  - Mercuri, Ludovica
A1  - Palmisano, Donato
A1  - L'Abbate, Alberto
A1  - D'Addabbo, Pietro
A1  - Montinaro, Francesco
A1  - Catacchio, Claudia Rita
A1  - Hasenfeld, Patrick
A1  - Ventura, Mario
A1  - Korbel, Jan O.
A1  - Sanders, Ashley D.
A1  - Maggiolini, Flavia Angela Maria
A1  - Antonacci, Francesca
T1  - A high-resolution map of small-scale inversions in the gibbon genome
Y1  - 2022/10/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1941 
EP  - 1951 
DO  - 10.1101/gr.276960.122 
VL  - 32 
IS  - 10 
UR  - http://genome.cshlp.org/content/32/10/1941.abstract 
N2  - Gibbons are the most speciose family of living apes, characterized by a diverse chromosome number and rapid rate of large-scale rearrangements. Here we performed single-cell template strand sequencing (Strand-seq), molecular cytogenetics, and deep in silico analysis of a southern white-cheeked gibbon genome, providing the first comprehensive map of 238 previously hidden small-scale inversions. We determined that more than half are gibbon specific, at least fivefold higher than shown for other primate lineage-specific inversions, with a significantly high number of small heterozygous inversions, suggesting that accelerated evolution of inversions may have played a role in the high sympatric diversity of gibbons. Although the precise mechanisms underlying these inversions are not yet understood, it is clear that segmental duplication–mediated NAHR only accounts for a small fraction of events. Several genomic features, including gene density and repeat (e.g., LINE-1) content, might render these regions more break-prone and susceptible to inversion formation. In the attempt to characterize interspecific variation between southern and northern white-cheeked gibbons, we identify several large assembly errors in the current GGSC Nleu3.0/nomLeu3 reference genome comprising more than 49 megabases of DNA. Finally, we provide a list of 182 candidate genes potentially involved in gibbon diversification and speciation. 
ER  -