@article{Mercuri01102022,
author = {Mercuri, Ludovica and Palmisano, Donato and L'Abbate, Alberto and D'Addabbo, Pietro and Montinaro, Francesco and Catacchio, Claudia Rita and Hasenfeld, Patrick and Ventura, Mario and Korbel, Jan O. and Sanders, Ashley D. and Maggiolini, Flavia Angela Maria and Antonacci, Francesca}, 
title = {A high-resolution map of small-scale inversions in the gibbon genome},
volume = {32}, 
number = {10}, 
pages = {1941-1951}, 
year = {2022}, 
doi = {10.1101/gr.276960.122}, 
abstract ={Gibbons are the most speciose family of living apes, characterized by a diverse chromosome number and rapid rate of large-scale rearrangements. Here we performed single-cell template strand sequencing (Strand-seq), molecular cytogenetics, and deep in silico analysis of a southern white-cheeked gibbon genome, providing the first comprehensive map of 238 previously hidden small-scale inversions. We determined that more than half are gibbon specific, at least fivefold higher than shown for other primate lineage-specific inversions, with a significantly high number of small heterozygous inversions, suggesting that accelerated evolution of inversions may have played a role in the high sympatric diversity of gibbons. Although the precise mechanisms underlying these inversions are not yet understood, it is clear that segmental duplication–mediated NAHR only accounts for a small fraction of events. Several genomic features, including gene density and repeat (e.g., LINE-1) content, might render these regions more break-prone and susceptible to inversion formation. In the attempt to characterize interspecific variation between southern and northern white-cheeked gibbons, we identify several large assembly errors in the current GGSC Nleu3.0/nomLeu3 reference genome comprising more than 49 megabases of DNA. Finally, we provide a list of 182 candidate genes potentially involved in gibbon diversification and speciation.}, 
URL = {http://genome.cshlp.org/content/32/10/1941.abstract}, 
eprint = {http://genome.cshlp.org/content/32/10/1941.full.pdf+html}, 
journal = {Genome Research} 
}