TY  - JOUR
A1  - Waldvogel, Ann-Marie
A1  - Pfenninger, Markus
T1  - Temperature dependence of spontaneous mutation rates
Y1  - 2021/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1582 
EP  - 1589 
DO  - 10.1101/gr.275168.120 
VL  - 31 
IS  - 9 
UR  - http://genome.cshlp.org/content/31/9/1582.abstract 
N2  - Mutation is the source of genetic variation and the fundament of evolution. Temperature has long been suggested to have a direct impact on realized spontaneous mutation rates. If mutation rates vary in response to environmental conditions, such as the variation of the ambient temperature through space and time, they should no longer be described as species-specific constants. By combining mutation accumulation with whole-genome sequencing in a multicellular organism, we provide empirical support to reject the null hypothesis of a constant, temperature-independent mutation rate. Instead, mutation rates depended on temperature in a U-shaped manner with increasing rates toward both temperature extremes. This relation has important implications for mutation-dependent processes in molecular evolution, processes shaping the evolution of mutation rates, and even the evolution of biodiversity as such. 
ER  -