RT Journal
A1 Coppieters, Wouter
A1 Karim, Latifa
A1 Georges, Michel
T1 SNP-based quantitative deconvolution of biological mixtures: application to the detection of cows with subclinical mastitis by whole-genome sequencing of tank milk
JF Genome Research 
JO Genome Research 
YR 2020 
FD August 01 
VO 30 
IS 8 
SP 1201 
OP 1207 
DO 10.1101/gr.256172.119 
UL http://genome.cshlp.org/content/30/8/1201.abstract 
AB Biological products of importance in food (e.g., milk) and medical (e.g., donor blood-derived products) sciences often correspond to mixtures of samples contributed by multiple individuals. Identifying which individuals contributed to the mixture and in what proportions may be of interest in several circumstances. We herein present a method that allows to do this by shallow whole-genome sequencing of the DNA in mixed samples from hundreds of donors. We show the efficacy of the approach for the detection of cows with subclinical mastitis by analysis of farms’ tank mixtures containing milk from as many as 500 cows.