RT Journal
A1 Yu, Ting
A1 Mu, Zengchao
A1 Fang, Zhaoyuan
A1 Liu, Xiaoping
A1 Gao, Xin
A1 Liu, Juntao
T1 TransBorrow: genome-guided transcriptome assembly by borrowing assemblies from different assemblers
JF Genome Research 
JO Genome Research 
YR 2020 
FD August 01 
VO 30 
IS 8 
SP 1181 
OP 1190 
DO 10.1101/gr.257766.119 
UL http://genome.cshlp.org/content/30/8/1181.abstract 
AB RNA-seq technology is widely used in various transcriptomic studies and provides great opportunities to reveal the complex structures of transcriptomes. To effectively analyze RNA-seq data, we introduce a novel transcriptome assembler, TransBorrow, which borrows the assemblies from different assemblers to search for reliable subsequences by building a colored graph from those borrowed assemblies. Then, by seeding reliable subsequences, a newly designed path extension strategy accurately searches for a transcript-representing path cover over each splicing graph. TransBorrow was tested on both simulated and real data sets and showed great superiority over all the compared leading assemblers.