TY - JOUR A1 - Yu, Ting A1 - Mu, Zengchao A1 - Fang, Zhaoyuan A1 - Liu, Xiaoping A1 - Gao, Xin A1 - Liu, Juntao T1 - TransBorrow: genome-guided transcriptome assembly by borrowing assemblies from different assemblers Y1 - 2020/08/01 JF - Genome Research JO - Genome Research SP - 1181 EP - 1190 DO - 10.1101/gr.257766.119 VL - 30 IS - 8 UR - http://genome.cshlp.org/content/30/8/1181.abstract N2 - RNA-seq technology is widely used in various transcriptomic studies and provides great opportunities to reveal the complex structures of transcriptomes. To effectively analyze RNA-seq data, we introduce a novel transcriptome assembler, TransBorrow, which borrows the assemblies from different assemblers to search for reliable subsequences by building a colored graph from those borrowed assemblies. Then, by seeding reliable subsequences, a newly designed path extension strategy accurately searches for a transcript-representing path cover over each splicing graph. TransBorrow was tested on both simulated and real data sets and showed great superiority over all the compared leading assemblers. ER -