RT Journal A1 Ramilowski, Jordan A. A1 Yip, Chi Wai A1 Agrawal, Saumya A1 Chang, Jen-Chien A1 Ciani, Yari A1 Kulakovskiy, Ivan V. A1 Mendez, Mickaël A1 Ooi, Jasmine Li Ching A1 Ouyang, John F. A1 Parkinson, Nick A1 Petri, Andreas A1 Roos, Leonie A1 Severin, Jessica A1 Yasuzawa, Kayoko A1 Abugessaisa, Imad A1 Akalin, Altuna A1 Antonov, Ivan V. A1 Arner, Erik A1 Bonetti, Alessandro A1 Bono, Hidemasa A1 Borsari, Beatrice A1 Brombacher, Frank A1 Cameron, Christopher J.F. A1 Cannistraci, Carlo Vittorio A1 Cardenas, Ryan A1 Cardon, Melissa A1 Chang, Howard A1 Dostie, Josée A1 Ducoli, Luca A1 Favorov, Alexander A1 Fort, Alexandre A1 Garrido, Diego A1 Gil, Noa A1 Gimenez, Juliette A1 Guler, Reto A1 Handoko, Lusy A1 Harshbarger, Jayson A1 Hasegawa, Akira A1 Hasegawa, Yuki A1 Hashimoto, Kosuke A1 Hayatsu, Norihito A1 Heutink, Peter A1 Hirose, Tetsuro A1 Imada, Eddie L. A1 Itoh, Masayoshi A1 Kaczkowski, Bogumil A1 Kanhere, Aditi A1 Kawabata, Emily A1 Kawaji, Hideya A1 Kawashima, Tsugumi A1 Kelly, S. Thomas A1 Kojima, Miki A1 Kondo, Naoto A1 Koseki, Haruhiko A1 Kouno, Tsukasa A1 Kratz, Anton A1 Kurowska-Stolarska, Mariola A1 Kwon, Andrew Tae Jun A1 Leek, Jeffrey A1 Lennartsson, Andreas A1 Lizio, Marina A1 López-Redondo, Fernando A1 Luginbühl, Joachim A1 Maeda, Shiori A1 Makeev, Vsevolod J. A1 Marchionni, Luigi A1 Medvedeva, Yulia A. A1 Minoda, Aki A1 Müller, Ferenc A1 Muñoz-Aguirre, Manuel A1 Murata, Mitsuyoshi A1 Nishiyori, Hiromi A1 Nitta, Kazuhiro R. A1 Noguchi, Shuhei A1 Noro, Yukihiko A1 Nurtdinov, Ramil A1 Okazaki, Yasushi A1 Orlando, Valerio A1 Paquette, Denis A1 Parr, Callum J.C. A1 Rackham, Owen J.L. A1 Rizzu, Patrizia A1 Sánchez Martinez, Diego Fernando A1 Sandelin, Albin A1 Sanjana, Pillay A1 Semple, Colin A.M. A1 Shibayama, Youtaro A1 Sivaraman, Divya M. A1 Suzuki, Takahiro A1 Szumowski, Suzannah C. A1 Tagami, Michihira A1 Taylor, Martin S. A1 Terao, Chikashi A1 Thodberg, Malte A1 Thongjuea, Supat A1 Tripathi, Vidisha A1 Ulitsky, Igor A1 Verardo, Roberto A1 Vorontsov, Ilya E. A1 Yamamoto, Chinatsu A1 Young, Robert S. A1 Baillie, J. Kenneth A1 Forrest, Alistair R.R. A1 Guigó, Roderic A1 Hoffman, Michael M. A1 Hon, Chung Chau A1 Kasukawa, Takeya A1 Kauppinen, Sakari A1 Kere, Juha A1 Lenhard, Boris A1 Schneider, Claudio A1 Suzuki, Harukazu A1 Yagi, Ken A1 de Hoon, Michiel J.L. A1 Shin, Jay W. A1 Carninci, Piero T1 Functional annotation of human long noncoding RNAs via molecular phenotyping JF Genome Research JO Genome Research YR 2020 FD July 01 VO 30 IS 7 SP 1060 OP 1072 DO 10.1101/gr.254219.119 UL http://genome.cshlp.org/content/30/7/1060.abstract AB Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression of 285 lncRNAs in human dermal fibroblasts and quantified cellular growth, morphological changes, and transcriptomic responses using Capped Analysis of Gene Expression (CAGE). Antisense oligonucleotides targeting the same lncRNAs exhibited global concordance, and the molecular phenotype, measured by CAGE, recapitulated the observed cellular phenotypes while providing additional insights on the affected genes and pathways. Here, we disseminate the largest-to-date lncRNA knockdown data set with molecular phenotyping (over 1000 CAGE deep-sequencing libraries) for further exploration and highlight functional roles for ZNF213-AS1 and lnc-KHDC3L-2.