TY  - JOUR
A1  - Maurano, Matthew T.
A1  - Ramaswami, Sitharam
A1  - Zappile, Paul
A1  - Dimartino, Dacia
A1  - Boytard, Ludovic
A1  - Ribeiro-dos-Santos, André M.
A1  - Vulpescu, Nicholas A.
A1  - Westby, Gael
A1  - Shen, Guomiao
A1  - Feng, Xiaojun
A1  - Hogan, Megan S.
A1  - Ragonnet-Cronin, Manon
A1  - Geidelberg, Lily
A1  - Marier, Christian
A1  - Meyn, Peter
A1  - Zhang, Yutong
A1  - Cadley, John
A1  - Ordoñez, Raquel
A1  - Luther, Raven
A1  - Huang, Emily
A1  - Guzman, Emily
A1  - Arguelles-Grande, Carolina
A1  - Argyropoulos, Kimon V.
A1  - Black, Margaret
A1  - Serrano, Antonio
A1  - Call, Melissa E.
A1  - Kim, Min Jae
A1  - Belovarac, Brendan
A1  - Gindin, Tatyana
A1  - Lytle, Andrew
A1  - Pinnell, Jared
A1  - Vougiouklakis, Theodore
A1  - Chen, John
A1  - Lin, Lawrence H.
A1  - Rapkiewicz, Amy
A1  - Raabe, Vanessa
A1  - Samanovic, Marie I.
A1  - Jour, George
A1  - Osman, Iman
A1  - Aguero-Rosenfeld, Maria
A1  - Mulligan, Mark J.
A1  - Volz, Erik M.
A1  - Cotzia, Paolo
A1  - Snuderl, Matija
A1  - Heguy, Adriana
T1  - Sequencing identifies multiple early introductions of SARS-CoV-2 to the New York City region
Y1  - 2020/12/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1781 
EP  - 1788 
DO  - 10.1101/gr.266676.120 
VL  - 30 
IS  - 12 
UR  - http://genome.cshlp.org/content/30/12/1781.abstract 
N2  - Effective public response to a pandemic relies upon accurate measurement of the extent and dynamics of an outbreak. Viral genome sequencing has emerged as a powerful approach to link seemingly unrelated cases, and large-scale sequencing surveillance can inform on critical epidemiological parameters. Here, we report the analysis of 864 SARS-CoV-2 sequences from cases in the New York City metropolitan area during the COVID-19 outbreak in spring 2020. The majority of cases had no recent travel history or known exposure, and genetically linked cases were spread throughout the region. Comparison to global viral sequences showed that early transmission was most linked to cases from Europe. Our data are consistent with numerous seeds from multiple sources and a prolonged period of unrecognized community spreading. This work highlights the complementary role of genomic surveillance in addition to traditional epidemiological indicators. 
ER  -