TY  - JOUR
A1  - Hughes, Jennifer F.
A1  - Skaletsky, Helen
A1  - Pyntikova, Tatyana
A1  - Koutseva, Natalia
A1  - Raudsepp, Terje
A1  - Brown, Laura G.
A1  - Bellott, Daniel W.
A1  - Cho, Ting-Jan
A1  - Dugan-Rocha, Shannon
A1  - Khan, Ziad
A1  - Kremitzki, Colin
A1  - Fronick, Catrina
A1  - Graves-Lindsay, Tina A.
A1  - Fulton, Lucinda
A1  - Warren, Wesley C.
A1  - Wilson, Richard K.
A1  - Owens, Elaine
A1  - Womack, James E.
A1  - Murphy, William J.
A1  - Muzny, Donna M.
A1  - Worley, Kim C.
A1  - Chowdhary, Bhanu P.
A1  - Gibbs, Richard A.
A1  - Page, David C.
T1  - Sequence analysis in Bos taurus reveals pervasiveness of X–Y arms races in mammalian lineages
Y1  - 2020/12/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1716 
EP  - 1726 
DO  - 10.1101/gr.269902.120 
VL  - 30 
IS  - 12 
UR  - http://genome.cshlp.org/content/30/12/1716.abstract 
N2  - Studies of Y Chromosome evolution have focused primarily on gene decay, a consequence of suppression of crossing-over with the X Chromosome. Here, we provide evidence that suppression of X–Y crossing-over unleashed a second dynamic: selfish X–Y arms races that reshaped the sex chromosomes in mammals as different as cattle, mice, and men. Using super-resolution sequencing, we explore the Y Chromosome of Bos taurus (bull) and find it to be dominated by massive, lineage-specific amplification of testis-expressed gene families, making it the most gene-dense Y Chromosome sequenced to date. As in mice, an X-linked homolog of a bull Y-amplified gene has become testis-specific and amplified. This evolutionary convergence implies that lineage-specific X–Y coevolution through gene amplification, and the selfish forces underlying this phenomenon, were dominatingly powerful among diverse mammalian lineages. Together with Y gene decay, X–Y arms races molded mammalian sex chromosomes and influenced the course of mammalian evolution. 
ER  -