@article{Wang01022019,
author = {Wang, Shiyan and Chen, Jiahuan and Garcia, Sara P. and Liang, Xiaodong and Zhang, Fang and Yan, Pengyi and Yu, Huijing and Wei, Weiting and Li, Zixuan and Wang, Jingfang and Le, Huangying and Han, Zeguang and Luo, Xusheng and Day, Daniel S. and Stevens, Sean M. and Zhang, Yan and Park, Peter J. and Liu, Zhi-jie and Sun, Kun and Yuan, Guo-cheng and Pu, William T. and Zhang, Bing}, 
title = {A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA},
volume = {29}, 
number = {2}, 
pages = {193-207}, 
year = {2019}, 
doi = {10.1101/gr.239053.118}, 
abstract ={Cell behaviors are dictated by epigenetic and transcriptional programs. Little is known about how extracellular stimuli modulate these programs to reshape gene expression and control cell behavioral responses. Here, we interrogated the epigenetic and transcriptional response of endothelial cells to VEGFA treatment and found rapid chromatin changes that mediate broad transcriptomic alterations. VEGFA-responsive genes were associated with active promoters, but changes in promoter histone marks were not tightly linked to gene expression changes. VEGFA altered transcription factor occupancy and the distal epigenetic landscape, which profoundly contributed to VEGFA-dependent changes in gene expression. Integration of gene expression, dynamic enhancer, and transcription factor occupancy changes induced by VEGFA yielded a VEGFA-regulated transcriptional regulatory network, which revealed that the small MAF transcription factors are master regulators of the VEGFA transcriptional program and angiogenesis. Collectively these results revealed that extracellular stimuli rapidly reconfigure the chromatin landscape to coordinately regulate biological responses.}, 
URL = {http://genome.cshlp.org/content/29/2/193.abstract}, 
eprint = {http://genome.cshlp.org/content/29/2/193.full.pdf+html}, 
journal = {Genome Research} 
}