RT Journal
A1 Rahmanian, Sorena
A1 Murad, Rabi
A1 Breschi, Alessandra
A1 Zeng, Weihua
A1 Mackiewicz, Mark
A1 Williams, Brian
A1 Davis, Carrie A.
A1 Roberts, Brian
A1 Meadows, Sarah
A1 Moore, Dianna
A1 Trout, Diane
A1 Zaleski, Chris
A1 Dobin, Alex
A1 Sei, Lei-Hoon
A1 Drenkow, Jorg
A1 Scavelli, Alex
A1 Gingeras, Thomas R.
A1 Wold, Barbara J.
A1 Myers, Richard M.
A1 Guigó, Roderic
A1 Mortazavi, Ali
T1 Dynamics of microRNA expression during mouse prenatal development
JF Genome Research 
JO Genome Research 
YR 2019 
FD November 01 
VO 29 
IS 11 
SP 1900 
OP 1909 
DO 10.1101/gr.248997.119 
UL http://genome.cshlp.org/content/29/11/1900.abstract 
AB MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct organ-specific and developmental stage–specific miRNA expression clusters, with an overall pattern of increasing organ-specific expression as embryonic development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by organ type rather than by species. An analysis of messenger RNA expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the expression of mRNAs specific to other developmental programs in the organ in which these miRNAs are expressed during embryonic development. Our results provide the most comprehensive time-course of miRNA expression as part of an integrated ENCODE reference data set for mouse embryonic development.