TY  - JOUR
A1  - Rahmanian, Sorena
A1  - Murad, Rabi
A1  - Breschi, Alessandra
A1  - Zeng, Weihua
A1  - Mackiewicz, Mark
A1  - Williams, Brian
A1  - Davis, Carrie A.
A1  - Roberts, Brian
A1  - Meadows, Sarah
A1  - Moore, Dianna
A1  - Trout, Diane
A1  - Zaleski, Chris
A1  - Dobin, Alex
A1  - Sei, Lei-Hoon
A1  - Drenkow, Jorg
A1  - Scavelli, Alex
A1  - Gingeras, Thomas R.
A1  - Wold, Barbara J.
A1  - Myers, Richard M.
A1  - Guigó, Roderic
A1  - Mortazavi, Ali
T1  - Dynamics of microRNA expression during mouse prenatal development
Y1  - 2019/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1900 
EP  - 1909 
DO  - 10.1101/gr.248997.119 
VL  - 29 
IS  - 11 
UR  - http://genome.cshlp.org/content/29/11/1900.abstract 
N2  - MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct organ-specific and developmental stage–specific miRNA expression clusters, with an overall pattern of increasing organ-specific expression as embryonic development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by organ type rather than by species. An analysis of messenger RNA expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the expression of mRNAs specific to other developmental programs in the organ in which these miRNAs are expressed during embryonic development. Our results provide the most comprehensive time-course of miRNA expression as part of an integrated ENCODE reference data set for mouse embryonic development. 
ER  -