@article{Rahmanian01112019,
author = {Rahmanian, Sorena and Murad, Rabi and Breschi, Alessandra and Zeng, Weihua and Mackiewicz, Mark and Williams, Brian and Davis, Carrie A. and Roberts, Brian and Meadows, Sarah and Moore, Dianna and Trout, Diane and Zaleski, Chris and Dobin, Alex and Sei, Lei-Hoon and Drenkow, Jorg and Scavelli, Alex and Gingeras, Thomas R. and Wold, Barbara J. and Myers, Richard M. and Guigó, Roderic and Mortazavi, Ali}, 
title = {Dynamics of microRNA expression during mouse prenatal development},
volume = {29}, 
number = {11}, 
pages = {1900-1909}, 
year = {2019}, 
doi = {10.1101/gr.248997.119}, 
abstract ={MicroRNAs (miRNAs) play a critical role as posttranscriptional regulators of gene expression. The ENCODE Project profiled the expression of miRNAs in an extensive set of organs during a time-course of mouse embryonic development and captured the expression dynamics of 785 miRNAs. We found distinct organ-specific and developmental stage–specific miRNA expression clusters, with an overall pattern of increasing organ-specific expression as embryonic development proceeds. Comparative analysis of conserved miRNAs in mouse and human revealed stronger clustering of expression patterns by organ type rather than by species. An analysis of messenger RNA expression clusters compared with miRNA expression clusters identifies the potential role of specific miRNA expression clusters in suppressing the expression of mRNAs specific to other developmental programs in the organ in which these miRNAs are expressed during embryonic development. Our results provide the most comprehensive time-course of miRNA expression as part of an integrated ENCODE reference data set for mouse embryonic development.}, 
URL = {http://genome.cshlp.org/content/29/11/1900.abstract}, 
eprint = {http://genome.cshlp.org/content/29/11/1900.full.pdf+html}, 
journal = {Genome Research} 
}