RT Journal
A1 Ren, Li
A1 Li, Wuhui
A1 Qin, Qinbo
A1 Dai, He
A1 Han, Fengming
A1 Xiao, Jun
A1 Gao, Xin
A1 Cui, Jialin
A1 Wu, Chang
A1 Yan, Xiaojing
A1 Wang, Guoliang
A1 Liu, Guiming
A1 Liu, Jia
A1 Li, Jiaming
A1 Wan, Zhong
A1 Yang, Conghui
A1 Zhang, Chun
A1 Tao, Min
A1 Wang, Jing
A1 Luo, Kaikun
A1 Wang, Shi
A1 Hu, Fangzhou
A1 Zhao, Rurong
A1 Li, Xuming
A1 Liu, Min
A1 Zheng, Hongkun
A1 Zhou, Rong
A1 Shu, Yuqin
A1 Wang, Yude
A1 Liu, Qinfeng
A1 Tang, Chenchen
A1 Duan, Wei
A1 Liu, Shaojun
T1 The subgenomes show asymmetric expression of alleles in hybrid lineages of Megalobrama amblycephala × Culter alburnus
JF Genome Research 
JO Genome Research 
YR 2019 
FD November 01 
VO 29 
IS 11 
SP 1805 
OP 1815 
DO 10.1101/gr.249805.119 
UL http://genome.cshlp.org/content/29/11/1805.abstract 
AB Hybridization drives rapid speciation by shaping novel genotypic and phenotypic profiles. Genomic incompatibility and transcriptome shock have been observed in hybrids, although this is rarer in animals than in plants. Using the newly sequenced genomes of the blunt snout bream (Megalobrama amblycephala [BSB]) and the topmouth culter (Culter alburnus [TC]), we focused on the sequence variation and gene expression changes in the reciprocal intergeneric hybrid lineages (F1–F3) of BSB × TC. A genome-wide transcriptional analysis identified 145–974 expressed recombinant genes in the successive generations of hybrid fish, suggesting the rapid emergence of allelic variation following hybridization. Some gradual changes of gene expression with additive and dominance effects and various cis and trans regulations were observed from F1 to F3 in the two hybrid lineages. These asymmetric patterns of gene expression represent the alternative strategies for counteracting deleterious effects of the subgenomes and improving adaptability of novel hybrids. Furthermore, we identified positive selection and additive expression patterns in transforming growth factor, beta 1b (tgfb1b), which may account for the morphological variations of the pharyngeal jaw in the two hybrid lineages. Our current findings provide insights into the evolution of vertebrate genomes immediately following hybridization.