TY  - JOUR
A1  - Ren, Li
A1  - Li, Wuhui
A1  - Qin, Qinbo
A1  - Dai, He
A1  - Han, Fengming
A1  - Xiao, Jun
A1  - Gao, Xin
A1  - Cui, Jialin
A1  - Wu, Chang
A1  - Yan, Xiaojing
A1  - Wang, Guoliang
A1  - Liu, Guiming
A1  - Liu, Jia
A1  - Li, Jiaming
A1  - Wan, Zhong
A1  - Yang, Conghui
A1  - Zhang, Chun
A1  - Tao, Min
A1  - Wang, Jing
A1  - Luo, Kaikun
A1  - Wang, Shi
A1  - Hu, Fangzhou
A1  - Zhao, Rurong
A1  - Li, Xuming
A1  - Liu, Min
A1  - Zheng, Hongkun
A1  - Zhou, Rong
A1  - Shu, Yuqin
A1  - Wang, Yude
A1  - Liu, Qinfeng
A1  - Tang, Chenchen
A1  - Duan, Wei
A1  - Liu, Shaojun
T1  - The subgenomes show asymmetric expression of alleles in hybrid lineages of Megalobrama amblycephala × Culter alburnus
Y1  - 2019/11/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1805 
EP  - 1815 
DO  - 10.1101/gr.249805.119 
VL  - 29 
IS  - 11 
UR  - http://genome.cshlp.org/content/29/11/1805.abstract 
N2  - Hybridization drives rapid speciation by shaping novel genotypic and phenotypic profiles. Genomic incompatibility and transcriptome shock have been observed in hybrids, although this is rarer in animals than in plants. Using the newly sequenced genomes of the blunt snout bream (Megalobrama amblycephala [BSB]) and the topmouth culter (Culter alburnus [TC]), we focused on the sequence variation and gene expression changes in the reciprocal intergeneric hybrid lineages (F1–F3) of BSB × TC. A genome-wide transcriptional analysis identified 145–974 expressed recombinant genes in the successive generations of hybrid fish, suggesting the rapid emergence of allelic variation following hybridization. Some gradual changes of gene expression with additive and dominance effects and various cis and trans regulations were observed from F1 to F3 in the two hybrid lineages. These asymmetric patterns of gene expression represent the alternative strategies for counteracting deleterious effects of the subgenomes and improving adaptability of novel hybrids. Furthermore, we identified positive selection and additive expression patterns in transforming growth factor, beta 1b (tgfb1b), which may account for the morphological variations of the pharyngeal jaw in the two hybrid lineages. Our current findings provide insights into the evolution of vertebrate genomes immediately following hybridization. 
ER  -