@article{Wang01092018,
author = {Wang, Isabel X. and Grunseich, Christopher and Fox, Jennifer and Burdick, Joshua and Zhu, Zhengwei and Ravazian, Niema and Hafner, Markus and Cheung, Vivian G.}, 
title = {Human proteins that interact with RNA/DNA hybrids},
volume = {28}, 
number = {9}, 
pages = {1405-1414}, 
year = {2018}, 
doi = {10.1101/gr.237362.118}, 
abstract ={RNA/DNA hybrids form when RNA hybridizes with its template DNA generating a three-stranded structure known as the R-loop. Knowledge of how they form and resolve, as well as their functional roles, is limited. Here, by pull-down assays followed by mass spectrometry, we identified 803 proteins that bind to RNA/DNA hybrids. Because these proteins were identified using in vitro assays, we confirmed that they bind to R-loops in vivo. They include proteins that are involved in a variety of functions, including most steps of RNA processing. The proteins are enriched for K homology (KH) and helicase domains. Among them, more than 300 proteins preferred binding to hybrids than double-stranded DNA. These proteins serve as starting points for mechanistic studies to elucidate what RNA/DNA hybrids regulate and how they are regulated.}, 
URL = {http://genome.cshlp.org/content/28/9/1405.abstract}, 
eprint = {http://genome.cshlp.org/content/28/9/1405.full.pdf+html}, 
journal = {Genome Research} 
}