TY  - JOUR
A1  - Pidsley, Ruth
A1  - Lawrence, Mitchell G.
A1  - Zotenko, Elena
A1  - Niranjan, Birunthi
A1  - Statham, Aaron
A1  - Song, Jenny
A1  - Chabanon, Roman M.
A1  - Qu, Wenjia
A1  - Wang, Hong
A1  - Richards, Michelle
A1  - Nair, Shalima S.
A1  - Armstrong, Nicola J.
A1  - Nim, Hieu T.
A1  - Papargiris, Melissa
A1  - Balanathan, Preetika
A1  - French, Hugh
A1  - Peters, Timothy
A1  - Norden, Sam
A1  - Ryan, Andrew
A1  - Pedersen, John
A1  - Kench, James
A1  - Daly, Roger J.
A1  - Horvath, Lisa G.
A1  - Stricker, Phillip
A1  - Frydenberg, Mark
A1  - Taylor, Renea A.
A1  - Stirzaker, Clare
A1  - Risbridger, Gail P.
A1  - Clark, Susan J.
T1  - Enduring epigenetic landmarks define the cancer microenvironment
Y1  - 2018/05/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 625 
EP  - 638 
DO  - 10.1101/gr.229070.117 
VL  - 28 
IS  - 5 
UR  - http://genome.cshlp.org/content/28/5/625.abstract 
N2  - The growth and progression of solid tumors involves dynamic cross-talk between cancer epithelium and the surrounding microenvironment. To date, molecular profiling has largely been restricted to the epithelial component of tumors; therefore, features underpinning the persistent protumorigenic phenotype of the tumor microenvironment are unknown. Using whole-genome bisulfite sequencing, we show for the first time that cancer-associated fibroblasts (CAFs) from localized prostate cancer display remarkably distinct and enduring genome-wide changes in DNA methylation, significantly at enhancers and promoters, compared to nonmalignant prostate fibroblasts (NPFs). Differentially methylated regions associated with changes in gene expression have cancer-related functions and accurately distinguish CAFs from NPFs. Remarkably, a subset of changes is shared with prostate cancer epithelial cells, revealing the new concept of tumor-specific epigenome modifications in the tumor and its microenvironment. The distinct methylome of CAFs provides a novel epigenetic hallmark of the cancer microenvironment and promises new biomarkers to improve interpretation of diagnostic samples. 
ER  -