RT Journal
A1 Li, Lishi
A1 Song, Yulong
A1 Shi, Xinrui
A1 Liu, Jianheng
A1 Xiong, Shaolei
A1 Chen, Wanying
A1 Fu, Qiang
A1 Huang, Zichao
A1 Gu, Nannan
A1 Zhang, Rui
T1 The landscape of miRNA editing in animals and its impact on miRNA biogenesis and targeting
JF Genome Research 
JO Genome Research 
YR 2018 
FD January 01 
VO 28 
IS 1 
SP 132 
OP 143 
DO 10.1101/gr.224386.117 
UL http://genome.cshlp.org/content/28/1/132.abstract 
AB Adenosine-to-inosine (A-to-I) RNA editing regulates miRNA biogenesis and function. To date, fewer than 160 miRNA editing sites have been identified. Here, we present a quantitative atlas of miRNA A-to-I editing through the profiling of 201 pri-miRNA samples and 4694 mature miRNA samples in human, mouse, and Drosophila. We identified 4162 sites present in ∼80% of the pri-miRNAs and 574 sites in mature miRNAs. miRNA editing is prevalent in many tissue types in human. However, high-level editing is mostly found in neuronal tissues in mouse and Drosophila. Interestingly, the edited miRNAs in neuronal and non-neuronal tissues in human gain two distinct sets of new targets, which are significantly associated with cognitive and organ developmental functions, respectively. Furthermore, we reveal that miRNA editing profoundly affects asymmetric strand selection. Altogether, these data provide insight into the impact of RNA editing on miRNA biology and suggest that miRNA editing has recently gained non-neuronal functions in human.