TY  - JOUR
A1  - Liu, Siling
A1  - Wang, Zhengbo
A1  - Chen, Dong
A1  - Zhang, Bowen
A1  - Tian, Ren-Rong
A1  - Wu, Jing
A1  - Zhang, Ying
A1  - Xu, Kaiyu
A1  - Yang, Liu-Meng
A1  - Cheng, Chao
A1  - Ma, Jian
A1  - Lv, Longbao
A1  - Zheng, Yong-Tang
A1  - Hu, Xintian
A1  - Zhang, Yi
A1  - Wang, Xiangting
A1  - Li, Jiali
T1  - Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain
Y1  - 2017/09/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1608 
EP  - 1620 
DO  - 10.1101/gr.217463.116 
VL  - 27 
IS  - 9 
UR  - http://genome.cshlp.org/content/27/9/1608.abstract 
N2  - Long noncoding RNAs (lncRNAs) mediate important epigenetic regulation in a wide range of biological processes and diseases. We applied comprehensive analyses of RNA-seq and CAGE-seq (cap analysis of gene expression and sequencing) to characterize the dynamic changes in lncRNA expression in rhesus macaque (Macaca mulatta) brain in four representative age groups. We identified 18 anatomically diverse lncRNA modules and 14 mRNA modules representing spatial, age, and sex specificities. Spatiotemporal- and sex-biased changes in lncRNA expression were generally higher than those observed in mRNA expression. A negative correlation between lncRNA and mRNA expression in cerebral cortex was observed and functionally validated. Our findings offer a fresh insight into spatial-, age-, and sex-biased changes in lncRNA expression in macaque brain and suggest that the changes represent a previously unappreciated regulatory system that potentially contributes to brain development and aging. 
ER  -