RT Journal
A1 Sriswasdi, Sira
A1 Takashima, Masako
A1 Manabe, Ri-ichiroh
A1 Ohkuma, Moriya
A1 Sugita, Takashi
A1 Iwasaki, Wataru
T1 Global deceleration of gene evolution following recent genome hybridizations in fungi
JF Genome Research 
JO Genome Research 
YR 2016 
FD August 01 
VO 26 
IS 8 
SP 1081 
OP 1090 
DO 10.1101/gr.205948.116 
UL http://genome.cshlp.org/content/26/8/1081.abstract 
AB Polyploidization events such as whole-genome duplication and inter-species hybridization are major evolutionary forces that shape genomes. Although long-term effects of polyploidization have been well-characterized, early molecular evolutionary consequences of polyploidization remain largely unexplored. Here, we report the discovery of two recent and independent genome hybridizations within a single clade of a fungal genus, Trichosporon. Comparative genomic analyses revealed that redundant genes are experiencing decelerations, not accelerations, of evolutionary rates. We identified a relationship between gene conversion and decelerated evolution suggesting that gene conversion may improve the genome stability of young hybrids by restricting gene functional divergences. Furthermore, we detected large-scale gene losses from transcriptional and translational machineries that indicate a global compensatory mechanism against increased gene dosages. Overall, our findings illustrate counteracting mechanisms during an early phase of post-genome hybridization and fill a critical gap in existing theories on genome evolution.