TY  - JOUR
A1  - Sriswasdi, Sira
A1  - Takashima, Masako
A1  - Manabe, Ri-ichiroh
A1  - Ohkuma, Moriya
A1  - Sugita, Takashi
A1  - Iwasaki, Wataru
T1  - Global deceleration of gene evolution following recent genome hybridizations in fungi
Y1  - 2016/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1081 
EP  - 1090 
DO  - 10.1101/gr.205948.116 
VL  - 26 
IS  - 8 
UR  - http://genome.cshlp.org/content/26/8/1081.abstract 
N2  - Polyploidization events such as whole-genome duplication and inter-species hybridization are major evolutionary forces that shape genomes. Although long-term effects of polyploidization have been well-characterized, early molecular evolutionary consequences of polyploidization remain largely unexplored. Here, we report the discovery of two recent and independent genome hybridizations within a single clade of a fungal genus, Trichosporon. Comparative genomic analyses revealed that redundant genes are experiencing decelerations, not accelerations, of evolutionary rates. We identified a relationship between gene conversion and decelerated evolution suggesting that gene conversion may improve the genome stability of young hybrids by restricting gene functional divergences. Furthermore, we detected large-scale gene losses from transcriptional and translational machineries that indicate a global compensatory mechanism against increased gene dosages. Overall, our findings illustrate counteracting mechanisms during an early phase of post-genome hybridization and fill a critical gap in existing theories on genome evolution. 
ER  -