@article{Sriswasdi01082016,
author = {Sriswasdi, Sira and Takashima, Masako and Manabe, Ri-ichiroh and Ohkuma, Moriya and Sugita, Takashi and Iwasaki, Wataru}, 
title = {Global deceleration of gene evolution following recent genome hybridizations in fungi},
volume = {26}, 
number = {8}, 
pages = {1081-1090}, 
year = {2016}, 
doi = {10.1101/gr.205948.116}, 
abstract ={Polyploidization events such as whole-genome duplication and inter-species hybridization are major evolutionary forces that shape genomes. Although long-term effects of polyploidization have been well-characterized, early molecular evolutionary consequences of polyploidization remain largely unexplored. Here, we report the discovery of two recent and independent genome hybridizations within a single clade of a fungal genus, Trichosporon. Comparative genomic analyses revealed that redundant genes are experiencing decelerations, not accelerations, of evolutionary rates. We identified a relationship between gene conversion and decelerated evolution suggesting that gene conversion may improve the genome stability of young hybrids by restricting gene functional divergences. Furthermore, we detected large-scale gene losses from transcriptional and translational machineries that indicate a global compensatory mechanism against increased gene dosages. Overall, our findings illustrate counteracting mechanisms during an early phase of post-genome hybridization and fill a critical gap in existing theories on genome evolution.}, 
URL = {http://genome.cshlp.org/content/26/8/1081.abstract}, 
eprint = {http://genome.cshlp.org/content/26/8/1081.full.pdf+html}, 
journal = {Genome Research} 
}