RT Journal
A1 Kadri, Naveen Kumar
A1 Harland, Chad
A1 Faux, Pierre
A1 Cambisano, Nadine
A1 Karim, Latifa
A1 Coppieters, Wouter
A1 Fritz, Sébastien
A1 Mullaart, Erik
A1 Baurain, Denis
A1 Boichard, Didier
A1 Spelman, Richard
A1 Charlier, Carole
A1 Georges, Michel
A1 Druet, Tom
T1 Coding and noncoding variants in HFM1, MLH3, MSH4, MSH5, RNF212, and RNF212B affect recombination rate in cattle
JF Genome Research 
JO Genome Research 
YR 2016 
FD October 01 
VO 26 
IS 10 
SP 1323 
OP 1332 
DO 10.1101/gr.204214.116 
UL http://genome.cshlp.org/content/26/10/1323.abstract 
AB We herein study genetic recombination in three cattle populations from France, New Zealand, and the Netherlands. We identify 2,395,177 crossover (CO) events in 94,516 male gametes, and 579,996 CO events in 25,332 female gametes. The average number of COs was found to be larger in males (23.3) than in females (21.4). The heritability of global recombination rate (GRR) was estimated at 0.13 in males and 0.08 in females, with a genetic correlation of 0.66 indicating that shared variants are influencing GRR in both sexes. A genome-wide association study identified seven quantitative trait loci (QTL) for GRR. Fine-mapping following sequence-based imputation in 14,401 animals pinpointed likely causative coding (5) and noncoding (1) variants in genes known to be involved in meiotic recombination (HFM1, MSH4, RNF212, MLH3, MSH5) for 5/7 QTL, and noncoding variants (3) in RNF212B for 1/7 QTL. This suggests that this RNF212 paralog might also be involved in recombination. Most of the identified mutations had significant effects in both sexes, with three of them each accounting for ∼10% of the genetic variance in males.