TY  - JOUR
A1  - Smith, Jeramiah J.
A1  - Keinath, Melissa C.
T1  - The sea lamprey meiotic map improves resolution of ancient vertebrate genome duplications
Y1  - 2015/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1081 
EP  - 1090 
DO  - 10.1101/gr.184135.114 
VL  - 25 
IS  - 8 
UR  - http://genome.cshlp.org/content/25/8/1081.abstract 
N2  - It is generally accepted that many genes present in vertebrate genomes owe their origin to two whole-genome duplications that occurred deep in the ancestry of the vertebrate lineage. However, details regarding the timing and outcome of these duplications are not well resolved. We present high-density meiotic and comparative genomic maps for the sea lamprey (Petromyzon marinus), a representative of an ancient lineage that diverged from all other vertebrates ∼550 million years ago. Linkage analyses yielded a total of 95 linkage groups, similar to the estimated number of germline chromosomes (1n ∼ 99), spanning a total of 5570.25 cM. Comparative mapping data yield strong support for the hypothesis that a single whole-genome duplication occurred in the basal vertebrate lineage, but do not strongly support a hypothetical second event. Rather, these comparative maps reveal several evolutionarily independent segmental duplications occurring over the last 600+ million years of chordate evolution. This refined history of vertebrate genome duplication should permit more precise investigations of vertebrate evolution. 
ER  -