TY  - JOUR
A1  - Baran, Yael
A1  - Subramaniam, Meena
A1  - Biton, Anne
A1  - Tukiainen, Taru
A1  - Tsang, Emily K.
A1  - Rivas, Manuel A.
A1  - Pirinen, Matti
A1  - Gutierrez-Arcelus, Maria
A1  - Smith, Kevin S.
A1  - Kukurba, Kim R.
A1  - Zhang, Rui
A1  - Eng, Celeste
A1  - Torgerson, Dara G.
A1  - Urbanek, Cydney
A1  - the GTEx Consortium
A1  - Li, Jin Billy
A1  - Rodriguez-Santana, Jose R.
A1  - Burchard, Esteban G.
A1  - Seibold, Max A.
A1  - MacArthur, Daniel G.
A1  - Montgomery, Stephen B.
A1  - Zaitlen, Noah A.
A1  - Lappalainen, Tuuli
T1  - The landscape of genomic imprinting across diverse adult human tissues
Y1  - 2015/07/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 927 
EP  - 936 
DO  - 10.1101/gr.192278.115 
VL  - 25 
IS  - 7 
UR  - http://genome.cshlp.org/content/25/7/927.abstract 
N2  - Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype-Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously identified genes. Tissue specificity of imprinting is widespread, and gender-specific effects are revealed in a small number of genes in muscle with stronger imprinting in males. IGF2 shows maternal expression in the brain instead of the canonical paternal expression elsewhere. Imprinting appears to have only a subtle impact on tissue-specific expression levels, with genes lacking a systematic expression difference between tissues with imprinted and biallelic expression. In summary, our systematic characterization of imprinting in adult tissues highlights variation in imprinting between genes, individuals, and tissues. 
ER  -