@article{Baran01072015,
author = {Baran, Yael and Subramaniam, Meena and Biton, Anne and Tukiainen, Taru and Tsang, Emily K. and Rivas, Manuel A. and Pirinen, Matti and Gutierrez-Arcelus, Maria and Smith, Kevin S. and Kukurba, Kim R. and Zhang, Rui and Eng, Celeste and Torgerson, Dara G. and Urbanek, Cydney and the GTEx Consortium and Li, Jin Billy and Rodriguez-Santana, Jose R. and Burchard, Esteban G. and Seibold, Max A. and MacArthur, Daniel G. and Montgomery, Stephen B. and Zaitlen, Noah A. and Lappalainen, Tuuli}, 
title = {The landscape of genomic imprinting across diverse adult human tissues},
volume = {25}, 
number = {7}, 
pages = {927-936}, 
year = {2015}, 
doi = {10.1101/gr.192278.115}, 
abstract ={Genomic imprinting is an important regulatory mechanism that silences one of the parental copies of a gene. To systematically characterize this phenomenon, we analyze tissue specificity of imprinting from allelic expression data in 1582 primary tissue samples from 178 individuals from the Genotype-Tissue Expression (GTEx) project. We characterize imprinting in 42 genes, including both novel and previously identified genes. Tissue specificity of imprinting is widespread, and gender-specific effects are revealed in a small number of genes in muscle with stronger imprinting in males. IGF2 shows maternal expression in the brain instead of the canonical paternal expression elsewhere. Imprinting appears to have only a subtle impact on tissue-specific expression levels, with genes lacking a systematic expression difference between tissues with imprinted and biallelic expression. In summary, our systematic characterization of imprinting in adult tissues highlights variation in imprinting between genes, individuals, and tissues.}, 
URL = {http://genome.cshlp.org/content/25/7/927.abstract}, 
eprint = {http://genome.cshlp.org/content/25/7/927.full.pdf+html}, 
journal = {Genome Research} 
}