TY  - JOUR
A1  - Ju, Young Seok
A1  - Tubio, Jose M.C.
A1  - Mifsud, William
A1  - Fu, Beiyuan
A1  - Davies, Helen R.
A1  - Ramakrishna, Manasa
A1  - Li, Yilong
A1  - Yates, Lucy
A1  - Gundem, Gunes
A1  - Tarpey, Patrick S.
A1  - Behjati, Sam
A1  - Papaemmanuil, Elli
A1  - Martin, Sancha
A1  - Fullam, Anthony
A1  - Gerstung, Moritz
A1  - ICGC Prostate Cancer Working Group
A1  - ICGC Bone Cancer Working Group
A1  - ICGC Breast Cancer Working Group
A1  - Nangalia, Jyoti
A1  - Green, Anthony R.
A1  - Caldas, Carlos
A1  - Borg, Åke
A1  - Tutt, Andrew
A1  - Lee, Ming Ta Michael
A1  - van't Veer, Laura J.
A1  - Tan, Benita K.T.
A1  - Aparicio, Samuel
A1  - Span, Paul N.
A1  - Martens, John W.M.
A1  - Knappskog, Stian
A1  - Vincent-Salomon, Anne
A1  - Børresen-Dale, Anne-Lise
A1  - Eyfjörd, Jórunn Erla
A1  - Myklebost, Ola
A1  - Flanagan, Adrienne M.
A1  - Foster, Christopher
A1  - Neal, David E.
A1  - Cooper, Colin
A1  - Eeles, Rosalind
A1  - Bova, G. Steven
A1  - Lakhani, Sunil R.
A1  - Desmedt, Christine
A1  - Thomas, Gilles
A1  - Richardson, Andrea L.
A1  - Purdie, Colin A.
A1  - Thompson, Alastair M.
A1  - McDermott, Ultan
A1  - Yang, Fengtang
A1  - Nik-Zainal, Serena
A1  - Campbell, Peter J.
A1  - Stratton, Michael R.
T1  - Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Y1  - 2015/06/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 814 
EP  - 824 
DO  - 10.1101/gr.190470.115 
VL  - 25 
IS  - 6 
UR  - http://genome.cshlp.org/content/25/6/814.abstract 
N2  - Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved. Remarkably, mitochondrial-nuclear genome fusions occur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the presence of a high frequency of contact between mitochondrial and nuclear DNA in some somatic cells. Transmission of mitochondrial DNA to the nuclear genome occurs in neoplastically transformed cells, but we do not exclude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years earlier in normal somatic cells. 
ER  -