TY - JOUR A1 - Karmin, Monika A1 - Saag, Lauri A1 - Vicente, Mário A1 - Sayres, Melissa A. Wilson A1 - Järve, Mari A1 - Talas, Ulvi Gerst A1 - Rootsi, Siiri A1 - Ilumäe, Anne-Mai A1 - Mägi, Reedik A1 - Mitt, Mario A1 - Pagani, Luca A1 - Puurand, Tarmo A1 - Faltyskova, Zuzana A1 - Clemente, Florian A1 - Cardona, Alexia A1 - Metspalu, Ene A1 - Sahakyan, Hovhannes A1 - Yunusbayev, Bayazit A1 - Hudjashov, Georgi A1 - DeGiorgio, Michael A1 - Loogväli, Eva-Liis A1 - Eichstaedt, Christina A1 - Eelmets, Mikk A1 - Chaubey, Gyaneshwer A1 - Tambets, Kristiina A1 - Litvinov, Sergei A1 - Mormina, Maru A1 - Xue, Yali A1 - Ayub, Qasim A1 - Zoraqi, Grigor A1 - Korneliussen, Thorfinn Sand A1 - Akhatova, Farida A1 - Lachance, Joseph A1 - Tishkoff, Sarah A1 - Momynaliev, Kuvat A1 - Ricaut, François-Xavier A1 - Kusuma, Pradiptajati A1 - Razafindrazaka, Harilanto A1 - Pierron, Denis A1 - Cox, Murray P. A1 - Sultana, Gazi Nurun Nahar A1 - Willerslev, Rane A1 - Muller, Craig A1 - Westaway, Michael A1 - Lambert, David A1 - Skaro, Vedrana A1 - Kovačevic´, Lejla A1 - Turdikulova, Shahlo A1 - Dalimova, Dilbar A1 - Khusainova, Rita A1 - Trofimova, Natalya A1 - Akhmetova, Vita A1 - Khidiyatova, Irina A1 - Lichman, Daria V. A1 - Isakova, Jainagul A1 - Pocheshkhova, Elvira A1 - Sabitov, Zhaxylyk A1 - Barashkov, Nikolay A. A1 - Nymadawa, Pagbajabyn A1 - Mihailov, Evelin A1 - Seng, Joseph Wee Tien A1 - Evseeva, Irina A1 - Migliano, Andrea Bamberg A1 - Abdullah, Syafiq A1 - Andriadze, George A1 - Primorac, Dragan A1 - Atramentova, Lubov A1 - Utevska, Olga A1 - Yepiskoposyan, Levon A1 - Marjanovic´, Damir A1 - Kushniarevich, Alena A1 - Behar, Doron M. A1 - Gilissen, Christian A1 - Vissers, Lisenka A1 - Veltman, Joris A. A1 - Balanovska, Elena A1 - Derenko, Miroslava A1 - Malyarchuk, Boris A1 - Metspalu, Andres A1 - Fedorova, Sardana A1 - Eriksson, Anders A1 - Manica, Andrea A1 - Mendez, Fernando L. A1 - Karafet, Tatiana M. A1 - Veeramah, Krishna R. A1 - Bradman, Neil A1 - Hammer, Michael F. A1 - Osipova, Ludmila P. A1 - Balanovsky, Oleg A1 - Khusnutdinova, Elza K. A1 - Johnsen, Knut A1 - Remm, Maido A1 - Thomas, Mark G. A1 - Tyler-Smith, Chris A1 - Underhill, Peter A. A1 - Willerslev, Eske A1 - Nielsen, Rasmus A1 - Metspalu, Mait A1 - Villems, Richard A1 - Kivisild, Toomas T1 - A recent bottleneck of Y chromosome diversity coincides with a global change in culture Y1 - 2015/04/01 JF - Genome Research JO - Genome Research SP - 459 EP - 466 DO - 10.1101/gr.186684.114 VL - 25 IS - 4 UR - http://genome.cshlp.org/content/25/4/459.abstract N2 - It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males. ER -