TY  - JOUR
A1  - Turelli, Priscilla
A1  - Castro-Diaz, Nathaly
A1  - Marzetta, Flavia
A1  - Kapopoulou, Adamandia
A1  - Raclot, Charlène
A1  - Duc, Julien
A1  - Tieng, Vannary
A1  - Quenneville, Simon
A1  - Trono, Didier
T1  - Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements
Y1  - 2014/08/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 1260 
EP  - 1270 
DO  - 10.1101/gr.172833.114 
VL  - 24 
IS  - 8 
UR  - http://genome.cshlp.org/content/24/8/1260.abstract 
N2  - Reverse transcription-derived sequences account for at least half of the human genome. Although these retroelements are formidable motors of evolution, they can occasionally cause disease, and accordingly are inactivated during early embryogenesis through epigenetic mechanisms. In the mouse, at least for endogenous retroviruses, important mediators of this process are the tetrapod-specific KRAB-containing zinc finger proteins (KRAB-ZFPs) and their cofactor TRIM28. The present study demonstrates that KRAB/TRIM28-mediated regulation is responsible for controlling a very broad range of human-specific endogenous retroelements (EREs) in human embryonic stem (ES) cells and that it exerts, as a consequence, a marked effect on the transcriptional dynamics of these cells. It further reveals reciprocal dependence between TRIM28 recruitment at specific families of EREs and DNA methylation. It finally points to the importance of persistent TRIM28-mediated control of ERE transcriptional impact beyond their presumed inactivation by DNA methylation. 
ER  -