RT Journal
A1 Chen, Yibin
A1 Chen, Qiang
A1 McEachin, Richard C.
A1 Cavalcoli, James D.
A1 Yu, Xiaochun
T1 H2A.B facilitates transcription elongation at methylated CpG loci
JF Genome Research 
JO Genome Research 
YR 2014 
FD April 01 
VO 24 
IS 4 
SP 570 
OP 579 
DO 10.1101/gr.156877.113 
UL http://genome.cshlp.org/content/24/4/570.abstract 
AB H2A.B is a unique histone H2A variant that only exists in mammals. Here we found that H2A.B is ubiquitously expressed in major organs. Genome-wide analysis of H2A.B in mouse ES cells shows that H2A.B is associated with methylated DNA in gene body regions. Moreover, H2A.B-enriched gene loci are actively transcribed. One typical example is that H2A.B is enriched in a set of differentially methylated regions at imprinted loci and facilitates transcription elongation. These results suggest that H2A.B positively regulates transcription elongation by overcoming DNA methylation in the transcribed region. It provides a novel mechanism by which transcription is regulated at DNA hypermethylated regions.