TY  - JOUR
A1  - Akagi, Keiko
A1  - Li, Jingfeng
A1  - Broutian, Tatevik R.
A1  - Padilla-Nash, Hesed
A1  - Xiao, Weihong
A1  - Jiang, Bo
A1  - Rocco, James W.
A1  - Teknos, Theodoros N.
A1  - Kumar, Bhavna
A1  - Wangsa, Danny
A1  - He, Dandan
A1  - Ried, Thomas
A1  - Symer, David E.
A1  - Gillison, Maura L.
T1  - Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability
Y1  - 2014/02/01 
JF  - Genome Research 
JO  - Genome Research 
SP  - 185 
EP  - 199 
DO  - 10.1101/gr.164806.113 
VL  - 24 
IS  - 2 
UR  - http://genome.cshlp.org/content/24/2/185.abstract 
N2  - Genomic instability is a hallmark of human cancers, including the 5% caused by human papillomavirus (HPV). Here we report a striking association between HPV integration and adjacent host genomic structural variation in human cancer cell lines and primary tumors. Whole-genome sequencing revealed HPV integrants flanking and bridging extensive host genomic amplifications and rearrangements, including deletions, inversions, and chromosomal translocations. We present a model of “looping” by which HPV integrant-mediated DNA replication and recombination may result in viral–host DNA concatemers, frequently disrupting genes involved in oncogenesis and amplifying HPV oncogenes E6 and E7. Our high-resolution results shed new light on a catastrophic process, distinct from chromothripsis and other mutational processes, by which HPV directly promotes genomic instability. 
ER  -