RT Journal
A1 Reid, Adam J.
A1 Blake, Damer P.
A1 Ansari, Hifzur R.
A1 Billington, Karen
A1 Browne, Hilary P.
A1 Bryant, Josephine
A1 Dunn, Matt
A1 Hung, Stacy S.
A1 Kawahara, Fumiya
A1 Miranda-Saavedra, Diego
A1 Malas, Tareq B.
A1 Mourier, Tobias
A1 Naghra, Hardeep
A1 Nair, Mridul
A1 Otto, Thomas D.
A1 Rawlings, Neil D.
A1 Rivailler, Pierre
A1 Sanchez-Flores, Alejandro
A1 Sanders, Mandy
A1 Subramaniam, Chandra
A1 Tay, Yea-Ling
A1 Woo, Yong
A1 Wu, Xikun
A1 Barrell, Bart
A1 Dear, Paul H.
A1 Doerig, Christian
A1 Gruber, Arthur
A1 Ivens, Alasdair C.
A1 Parkinson, John
A1 Rajandream, Marie-Adèle
A1 Shirley, Martin W.
A1 Wan, Kiew-Lian
A1 Berriman, Matthew
A1 Tomley, Fiona M.
A1 Pain, Arnab
T1 Genomic analysis of the causative agents of coccidiosis in domestic chickens
JF Genome Research 
JO Genome Research 
YR 2014 
FD October 01 
VO 24 
IS 10 
SP 1676 
OP 1685 
DO 10.1101/gr.168955.113 
UL http://genome.cshlp.org/content/24/10/1676.abstract 
AB Global production of chickens has trebled in the past two decades and they are now the most important source of dietary animal protein worldwide. Chickens are subject to many infectious diseases that reduce their performance and productivity. Coccidiosis, caused by apicomplexan protozoa of the genus Eimeria, is one of the most important poultry diseases. Understanding the biology of Eimeria parasites underpins development of new drugs and vaccines needed to improve global food security. We have produced annotated genome sequences of all seven species of Eimeria that infect domestic chickens, which reveal the full extent of previously described repeat-rich and repeat-poor regions and show that these parasites possess the most repeat-rich proteomes ever described. Furthermore, while no other apicomplexan has been found to possess retrotransposons, Eimeria is home to a family of chromoviruses. Analysis of Eimeria genes involved in basic biology and host-parasite interaction highlights adaptations to a relatively simple developmental life cycle and a complex array of co-expressed surface proteins involved in host cell binding.